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Can you add a study site at a later stage, i.e. while the CT is running as subcontractor although centers with the same tasks are listed as "partners" in the initial proposal?
In this case you will have to make an amendment to your grant agreement. I understand that it is getting more difficult to add amendments. I would recommend to plan as conservative as possible and try to include "enough" study sites. We are not sure how high drop-out rates will be handled.